Does the UK’s decision to leave the EU (Brexit) justify a second referendum?

On 31st January 2020, Britain left the European Union. Yet, 62% of the Scottish people had voted in June 2016 that Britain should remain. Does this divergence justify Scottish demands for independence, following in the footsteps of the USA in 1776, Ireland in 1919, or India in 1948?

Or does the earlier referendum on independence in 2014, which came down 55:45 against independence, and which was promised as a once in a generation vote, mean new calls for independence are not justified?